Elegant studies revealed that, the special mechanism of SCOT catalyzing the formation of acetoacetyl CoA is generating the thioester with coenzyme A and binding the ADP groups of coenzyme A in the form of non – covalent bond. 研究表明:SCOT催化乙酰乙酰辅酶A生成的具体机制是与辅酶A的巯基生成硫酯并以非共价键的形式连接辅酶A的ADP基团。